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The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as either promoters or inhibitors of cell death.
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Bcl-2 ( B-cell lymphoma 2 ), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death ( apoptosis ), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. [5] [6] It was the first apoptosis regulator identified in any organism. [7]
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BCL-2 family isoforms in apoptosis and cancer - PMC
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